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Updated: Jun 20, 2026

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
Published on: April 16, 2012
Immunosuppressive drugs and Tregs: a critical evaluation!
Sacha A De Serres1, Mohamed H Sayegh, Nader Najafian
1Brigham and Women's Hospital, Boston, MA 02115, USA.
Abstract:
To define therapeutic strategies that promote tolerance, it is of critical importance to determine the effects of immunosuppressive drugs on regulatory T cells (Tregs). This review discusses the current knowledge about the physiology of Tregs in humans, the role or Tregs in transplantation, and the impact of the different types of immunosuppressive agents on the frequency and functionality of Tregs in in vitro and in vivo systems.
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