Related Experiment Video
Updated: Jun 20, 2026
14:06
Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays
Published on: November 12, 2012
In silico Reconstruction of the Metabolic and Pathogenic Potential of Bacterial Genomes Using Subsystems
Genome Dynamics
|August 22, 2009
Summary
Genome sequencing advances microbial research, enabling metabolic predictions. This review explores subsystem-based tools for analyzing microbial pathogens and their host interactions, aiding comparative genomics and pathogenomics.
Area of Science:
- Microbiology
- Bioinformatics
- Genomics
Background:
- Whole genome sequencing is transforming biological sciences, particularly microbiology.
- Bioinformatics tools now allow prediction of organism metabolism from genomic data.
- Predicting pathogenic potential and host interactions of parasitic microbes remains challenging.
Purpose of the Study:
- Introduce subsystem-based technology for genome annotation and analysis.
- Discuss available subsystem-based tools within the National Microbial Pathogen Data Resource (NMPDR).
- Explore applications in comparative genomics and pathogenomics.
Main Methods:
- Genome annotation using subsystem-based technology.
- Utilizing bioinformatics tools from the National Microbial Pathogen Data Resource (NMPDR).
- Comparative analysis of microbial genomes.
Main Results:
- Subsystem-based technology provides a framework for genome annotation.
- NMPDR offers tools applicable to pathogenomics.
- Potential for enhanced understanding of microbial pathogenesis.
Conclusions:
- Subsystem-based approaches are valuable for microbial genome analysis.
- NMPDR tools can advance pathogenomics research.
- Further development is needed to fully predict pathogenic potential and host interactions.
Related Concept Videos
01:29Modern Molecular Taxonomy
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
01:24Biosynthesis in Bacteria
Biosynthesis in bacteria is a fundamental anabolic process that generates essential macromolecules, including proteins, nucleic acids, lipids, and polysaccharides. These macromolecules are critical for cellular growth, replication, and function. The process is tightly regulated and energetically linked to catabolic pathways to ensure optimal resource utilization.Biosynthetic pathways begin with precursor metabolites such as pyruvate, acetyl-CoA, and glucose-6-phosphate derived from glycolysis,...
02:55Synthetic Biology
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
Golden rice
Golden rice is a genetically modified...
01:08Evolution of Microbial Genome
Microbial genome evolution is a highly dynamic process shaped by continual gene gain and loss across species and strains. This genomic flexibility allows microorganisms to adapt rapidly to environmental pressures and interactions with other organisms. Central to understanding this diversity is the distinction between the core and pan genomes.The core genome comprises the genes shared by all sampled strains of a species, representing essential functions needed for fundamental cellular processes.
01:22Phylogenetic Species Concept in Microbiology
The phylogenetic species concept (PSC) is a framework used to delineate species based on evolutionary relationships, emphasizing shared ancestry and diagnosable genetic traits. Unlike morphological or biological species concepts, the PSC is particularly advantageous for microbial taxonomy, where traditional reproductive or phenotypic criteria often fall short due to the prevalence of asexual reproduction, minimal morphological differentiation, and widespread horizontal gene transfer among...
01:24Microbial Classification System
Classification is the process of organizing organisms into hierarchically inclusive groups based on their phenotypic similarities or evolutionary relationships. A species comprises one or more strains, and closely related species are grouped into genera. Genera are further classified into families, families into orders, orders into classes, and so forth, up to the domain level, which is the broadest taxonomic rank derived from a combination of phenotypic and genotypic data.The nomenclature of...