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Updated: Jun 20, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

Genetic testing of athletes.

Alun G Williams, Henning Wackerhage

Medicine and Sport Science

|August 22, 2009

Summary

Genetic testing for sports performance and injury risk is currently not scientifically supported. Ethical concerns regarding athlete genetic data usage and potential abuse require further discussion.

Area of Science:

Sports Science
Genetics
Exercise Physiology

Background:

Genetic testing is increasingly available for predicting athletic performance and injury risk.
Various stakeholders, including athletes, coaches, physicians, and insurers, are interested in sport-related genetic information.
The application of genetic tests in sports contexts raises significant ethical considerations.

Purpose of the Study:

To evaluate the scientific validity of using genetic tests for predicting athletic performance and exercise-related injury or illness.
To explore the ethical implications surrounding the use of genetic testing in sports, particularly for young athletes.
To highlight the current limitations of genetic tests in informing critical decisions in sports.

Main Methods:

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Literature review of current scientific evidence on genetic testing in sports.

Analysis of potential applications of genetic tests in athlete selection, training individualization, and risk assessment.

Discussion of ethical challenges, including data privacy, consent, and potential for discrimination.

Main Results:

Current evidence suggests that commercially available genetic tests lack the predictive power for informed decision-making in sports.
The scientific justification for many proposed uses of genetic tests in sports is currently weak.
Significant ethical issues arise from third-party imposition of genetic tests, especially on minors.

Conclusions:

The predictive capabilities of current genetic tests are insufficient for reliable application in sports performance and injury risk assessment.
Ethical debates are crucial to ensure responsible use of existing and future genetic technologies in athletics.
Guidelines are needed to prevent potential abuse and ensure ethical application of genetic testing in sport.