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Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
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Fast and sensitive pretargeted labeling of cancer cells through a tetrazine/trans-cyclooctene cycloaddition

Neal K Devaraj1, Rabi Upadhyay, Jered B Haun

  • 1Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, Suite 5.210, Boston, MA 02114, USA.

Angewandte Chemie (International Ed. in English)
|August 22, 2009
PubMed
Abstract

No abstract available in PubMed .

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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