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Published on: August 9, 2022
Structural and thermal characterization of zolpidem hemitartrate hemihydrate (Form E) and its decomposition products
Ivan Halasz1, Robert E Dinnebier
1Max-Planck Institute for Solid State Research, Stuttgart, Germany. i.halasz@fkf.mpg.de
Abstract:
The crystal structure of zolpidem hemitartrate hemihydrate (I, Form E) has been solved from high-resolution laboratory powder diffraction data. It crystallizes in the orthorhombic P2(1)2(1)2(1) space group with a = 22.4664(6) A, b = 26.0420(7) A, and c = 7.4391(1) A. Protonation of zolpidem molecules could not be unambiguously determined. Thermal stability of Form E has been investigated by TG-DTA and in situ by temperature resolved X-ray powder diffraction. Water loss occurs between 50 degrees C
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