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Updated: Jun 20, 2026

Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer
Published on: February 10, 2023
Intraperitoneal immunotherapy to prevent peritoneal carcinomatosis in patients with advanced gastrointestinal
Michael A Ströhlein1, Markus M Heiss
1Department of Abdominal, Vascular and Transplant Surgery, Medical Center Cologne-Merheim, University of Witten/Herdecke, Cologne, Germany.
Abstract:
Prognosis of peritoneal carcinomatosis (PC) from GI tract cancers remains poor. As 30% of patients develop PC after curative surgery, prevention of PC during cancer resection would be desirable. Regarding physiopathology of PC and intraperitoneal immunology, intraoperative application of trifunctional antibodies offers advanced opportunities for destruction of intraperitoneal tumor cells and prevention of PC. First results indicated, the intraoperative treatment with trifunctional antibodies was safe and clinically feasible. Long-term results will be available in 2010.
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