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Related Experiment Video

Updated: Jun 20, 2026

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis
10:58

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis

Published on: July 18, 2016

Ovarian cancer: lymph node metastases.

G Balbi1, M A Manganaro, A Monteverde

  • 1Department Obstetrics and Gynecology, Second University of Study of Naples, Naples, Italy. giancarlo.balbi@unina2.it

European Journal of Gynaecological Oncology
|August 25, 2009
PubMed
Summary

Ovarian cancer frequently involves both pelvic and paraaortic lymph nodes. Bilateral lymphadenectomy is crucial for accurate staging and treating micrometastases in epithelial ovarian cancer patients.

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Area of Science:

  • Gynecologic Oncology
  • Surgical Pathology

Background:

  • Epithelial ovarian cancer (EOC) staging relies on accurate assessment of lymph node metastasis.
  • Understanding the patterns of nodal spread is critical for effective treatment strategies.

Purpose of the Study:

  • To investigate the prevalence and patterns of pelvic and paraaortic lymph node involvement in patients with advanced epithelial ovarian cancer.

Main Methods:

  • A cohort of 60 patients with FIGO Stages II-IV EOC underwent systematic pelvic and paraaortic lymphadenectomy between 1995 and 2006.
  • Surgical specimens were analyzed for nodal metastases.

Main Results:

  • Paraaortic lymph node metastases were found in 75% of patients, and pelvic nodal metastases in 70%.

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  • Isolated paraaortic involvement occurred in 20%, while isolated pelvic involvement was seen in 15%.
  • Common sites for metastases included paracaval (56%), external iliac (60%), and obturator (55%) lymph nodes.

    • Conclusions:

    • Nodal involvement is a significant factor in epithelial ovarian cancer, with a high incidence of both pelvic and paraaortic metastases.
    • Bilateral pelvic and paraaortic lymphadenectomy is essential for precise staging and treatment of micrometastases, even in cases of unilateral tumors.