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Antibody responses in oral fluid after administration of prophylactic human papillomavirus vaccines

Ali Rowhani-Rahbar1, Joseph J Carter, Stephen E Hawes

  • 1Department of Epidemiology, University of Washington, Seattle, WA 98125, USA. rowhani@u.washington.edu

The Journal of Infectious Diseases
|August 25, 2009
PubMed

We sought to determine whether oral fluid can be used to assess serum human papillomavirus (HPV) antibody status by enrolling women who had received a prophylactic HPV-16 vaccine in a new follow-up study. After the prophylactic HPV-6/11/16/18 vaccine was licensed in the United States, we administered it to consenting participants. With serologic findings used as the reference standard, The sensitivity of oral fluid was 49.6% (95% confidence interval [CI], 42.0%-57.3%) before and 100% (95% CI, 92.0%-100%) after administration of the quadrivalent vaccine. Oral fluid may have the potential to be used for monitoring of prophylactic HPV vaccines in the future.

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