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Progestin and antiprogestin interactions with progesterone receptors in human myomas
U Vij1, K Murugesan, K R Laumas
1Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi.
Abstract:
Progesterone receptors (PRs) in human fibromyomata (myomas) and normal myometrium were characterized by gel filtration, sucrose gradient sedimentation analysis, isoelectrofocusing and ligand specificity. The PR population in myoma tissues, 1242 +/- 505 fmol/mg protein, was 3-fold higher than normal myometrial tissues under similar hormonal milieu. The increased PR concentration in myomas appears to be of potential importance in physiopathology of fibromyoma.