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An NcoI restriction fragment length polymorphism at the human steroid sulphatase gene locus
P M van Zandvoort1, C A van Bennekom, H H Ropers
1Department of Human Genetics, University Hospital of Nijmegen, The Netherlands.
Human Genetics
|April 1, 1990
Abstract:
The DNA diagnosis of X-linked recessive ichthyosis vulgaris (incidence: approx. 1 in 5000 males) can be complicated by the absence of restriction fragment length polymorphisms (RFLPs) in the STS (steroid sulphatase) gene. An RFLP sequence in NcoI-digested genomic DNA is reported, which it is hoped may prove helpful in diagnosis.