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Related Concept Videos

Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as a...

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Related Experiment Video

Updated: Jun 20, 2026

The Tail Suspension Test
10:17

The Tail Suspension Test

Published on: January 28, 2012

Fetal malformations under lithium treatment.

G Eikmeier

    European Psychiatry : the Journal of the Association of European Psychiatrists
    |August 25, 2009
    PubMed
    Summary

    This case study highlights severe fetal malformations, including kidney agenesis and cardiac defects, associated with lithium treatment during early pregnancy. Further research is needed to understand these risks.

    Area of Science:

    • Obstetrics and Gynecology
    • Teratology
    • Pharmacology

    Background:

    • Lithium is a mood stabilizer commonly prescribed for bipolar disorder.
    • Exposure during pregnancy, particularly the first trimester, raises concerns regarding potential teratogenic effects.
    • Fetal malformations represent a significant risk associated with certain maternal medications.

    Purpose of the Study:

    • To present a case of severe fetal malformations.
    • To investigate the potential association between continuous lithium treatment in the first trimester and observed congenital anomalies.
    • To contribute to the understanding of lithium's teratogenic potential.

    Main Methods:

    • Case report presentation.
    • Review of medical history and prenatal records.

    Related Experiment Videos

    Last Updated: Jun 20, 2026

    The Tail Suspension Test
    10:17

    The Tail Suspension Test

    Published on: January 28, 2012

  • Detailed description of fetal malformations identified.

    • Main Results:

    • The fetus presented with bilateral renal agenesis (absent kidneys).
    • A severe cardiac defect was diagnosed.
    • These malformations occurred in a fetus exposed to continuous lithium treatment throughout the first trimester of pregnancy.

    Conclusions:

    • Continuous lithium exposure in the first trimester may be associated with severe fetal malformations, including renal and cardiac anomalies.
    • This case underscores the importance of careful risk-benefit assessment for lithium use during pregnancy.
    • Further investigation and data collection are crucial to elucidate the teratogenic profile of lithium.