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Related Concept Videos

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Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
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Related Experiment Video

Updated: Jun 20, 2026

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
08:02

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Published on: April 25, 2016

Cortisol-binding globulin levels in bipolar disorder.

E Vieta1, C Gastó, M M Osaba

  • 1Department of Psychiatry, Hospital Clinic, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain.

European Psychiatry : the Journal of the Association of European Psychiatrists
|August 25, 2009
PubMed
Summary
This summary is machine-generated.

Cortisol-binding globulin (CBG) levels are lower in men with bipolar disorder, suggesting a link between this protein and chronic stress in affective illness. These findings hold true even during remission periods.

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Area of Science:

  • Neuroendocrinology
  • Psychiatry
  • Biochemistry

Background:

  • Cortisol-binding globulin (CBG) is a potential biomarker for chronic stress.
  • Previous studies suggest CBG's involvement in stress-related conditions.

Purpose of the Study:

  • To investigate serum CBG concentrations in bipolar I disorder patients during remission.
  • To explore the relationship between CBG, cortisol, and lithium levels in bipolar disorder.

Main Methods:

  • Radioimmunoassay with monoclonal antibodies was used to measure serum CBG levels.
  • 39 RDC bipolar I patients in remission and 21 healthy controls were analyzed.
  • Plasma cortisol and serum lithium levels were also determined.

Main Results:

  • Bipolar males exhibited significantly lower serum CBG levels compared to healthy controls.
  • Serum CBG levels in bipolar females were similar to those in controls.
  • No significant correlation was found between CBG levels and cortisol or lithium concentrations.

Conclusions:

  • CBG levels are impacted by chronic affective illness, including bipolar disorder, even in remission.
  • The observed differences in CBG levels appear to be sex-specific in bipolar disorder.
  • CBG may serve as a relevant biological marker in the context of bipolar disorder.