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Searching for a predictive peripherical biological model in parasuicidal behaviour.

P Sáiz, J Bobes, M Gonzalez

    European Psychiatry : the Journal of the Association of European Psychiatrists
    |August 25, 2009
    PubMed
    Summary

    Researchers identified cholesterol and cortisol as potential biological markers for early detection of parasuicidal behavior. This could lead to inexpensive suicide risk assessment using blood tests.

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    Area of Science:

    • Biochemistry
    • Clinical Psychology
    • Medical Diagnostics

    Background:

    • Parasuicidal behavior presents a significant public health challenge.
    • Early detection of suicide risk is crucial for timely intervention.
    • Peripheral biological markers offer a potential avenue for objective risk assessment.

    Purpose of the Study:

    • To identify peripheral lipidic and hormonal markers for early detection of parasuicidal behavior.
    • To develop a predictive biological model for parasuicidal behavior.
    • To assess the potential of serum cholesterol and cortisol as inexpensive suicide risk markers.

    Main Methods:

    • A case-control study involving 128 patients who attempted suicide and a control group.
    • Measurement of lipidic (cholesterol, HDL-C, LDL-C) and hormonal (cortisol) profiles.
    • Discriminant analysis to establish a predictive biological model.

    Main Results:

    • The predictive model included cholesterol, HDL-C, LDL-C, and cortisol.
    • The model achieved a sensitivity of 62.5% and specificity of 65.6%.
    • Serum cholesterol and cortisol levels showed potential as accessible markers.

    Conclusions:

    • Serum cholesterol and cortisol levels may serve as cost-effective and readily available markers for suicide risk.
    • Further prospective studies are needed to replicate and refine this predictive model.
    • Biological markers could enhance early detection and prevention strategies for parasuicidal behavior.