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Multidrug resistance due to P-glycoprotein
R K Burt1, A T Fojo, S S Thorgeirsson
1Division of Cancer Etiology, National Cancer Institute.
Hospital Practice (Office Ed.)
|April 15, 1990
Summary
P-glycoprotein, an efflux pump in human tissues, protects cells from toxins but aids cancer drug resistance. Inhibiting this protein may enhance chemotherapy effectiveness and reduce toxicity.
Area of Science:
- Biochemistry
- Cell Biology
- Pharmacology
Background:
- P-glycoprotein is a key cell membrane efflux pump found in various human tissues.
- It plays a role in protecting normal cells from environmental toxins.
- This protein is also implicated in multidrug resistance in cancer cells, reducing chemotherapy efficacy.
Purpose of the Study:
- To explore the role of P-glycoprotein in cellular defense and drug resistance.
- To investigate the potential of P-glycoprotein inhibitors in cancer therapy.
Main Methods:
- The study focuses on the known functions and genetic basis of P-glycoprotein.
- It reviews the mechanism of action as an efflux pump.
- It discusses the implications of P-glycoprotein activity in both normal and cancerous cells.
Main Results:
- P-glycoprotein functions as a protective efflux pump against xenobiotics.
- Cancer cells utilize P-glycoprotein to develop resistance to chemotherapeutic agents.
- The gene encoding P-glycoprotein has been partially identified.
Conclusions:
- Targeting P-glycoprotein in tumors presents a promising strategy to overcome chemotherapy resistance.
- Inhibiting P-glycoprotein could lead to more effective and less toxic cancer treatments.