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Updated: Jun 20, 2026

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
Published on: September 21, 2011
Interactions of sex hormone-binding globulin with target cells
William Rosner1, Daniel J Hryb, Scott M Kahn
1Department of Medicine, St. Luke's/Roosevelt Hospital Center, College of, Physicians and Surgeons, Columbia University, New York, NY 10019, USA. wr7@columbia.edu
Abstract:
Sex hormone-binding globulin (SHBG) was initially described as a plasma protein synthesized in, and secreted by, the liver. It was discovered by its ability to bind certain androgens and estrogens and, for many years, was believed to serve as a transporter/reservoir for the steroids which it bound. Subsequently, it became clear that the cell membranes of selected tissues contained a receptor for SHBG (R(SHBG)). This review deals with what is known of that receptor - its anatomy, physiology and biochemistry.
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