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Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice
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Published on: November 11, 2021

Energy expenditure and aging.

Todd M Manini1

  • 1University of Florida, Institute on Aging, Department of Aging and Geriatric Research, 210 E Mowry Rd, PO Box 112610, Gainesville, FL 32611-2610, United States. tmanini@aging.ufl.edu

Ageing Research Reviews
|August 25, 2009
PubMed
Summary
This summary is machine-generated.

Energy expenditure (EE) declines with age due to reduced resting metabolic rate (RMR) and activity. Brain-based neuromodulators may control this age-related decrease in activity EE, impacting lifespan.

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Area of Science:

  • Gerontology
  • Metabolic Science
  • Neuroscience

Background:

  • Total energy expenditure (EE) significantly decreases in advanced human age.
  • This decline results from reduced resting metabolic rate (RMR) and activity EE.
  • While RMR changes are linked to organ mass and tissue metabolism, activity EE's decline is less understood.

Purpose of the Study:

  • To investigate the age-related decline in activity energy expenditure (EE).
  • To explore potential brain-based neuromodulatory mechanisms influencing activity EE and lifespan.

Main Methods:

  • Review of existing literature on energy expenditure, aging, and neuromodulators.
  • Analysis of factors contributing to reduced resting metabolic rate (RMR) and activity EE in aging.
  • Identification of candidate neuromodulators (orexin, agouti-related proteins, dopaminergic pathways) potentially involved.

Main Results:

  • Age-related reduction in activity EE is not fully explained by anatomical changes affecting RMR.
  • Brain-based biological control centers are implicated in regulating activity EE.
  • Neuromodulators like orexin, agouti-related proteins, and dopaminergic pathways are potential candidates.

Conclusions:

  • Activity EE plays a crucial role in determining lifespan.
  • Further research is needed to elucidate the biological mechanisms underlying age-related decreases in activity EE.
  • Understanding energy expenditure is key to unlocking insights into the aging process.