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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

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Related Experiment Video

Updated: Jun 20, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Malignant melanoma.

Joseph Califano1, Melonie Nance

  • 1Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA. jcalifa1@jhmi.edu

Facial Plastic Surgery Clinics of North America
|August 25, 2009
PubMed
Summary
This summary is machine-generated.

Early detection and treatment are key for curing malignant melanoma, the deadliest skin cancer. This review covers clinical presentation, staging, and treatment outcomes for improved patient survival.

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Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
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Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

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Related Experiment Videos

Last Updated: Jun 20, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
05:46

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Malignant melanoma is the most lethal form of skin cancer.
  • Early recognition and treatment are crucial for a positive patient outcome.
  • Physician and patient awareness are vital for timely diagnosis and cure.

Purpose of the Study:

  • To provide an in-depth discussion of malignant melanoma.
  • To cover clinical presentation, evaluation, and growth patterns.
  • To outline pathologic staging, treatment approaches, and outcomes.

Main Methods:

  • Review of clinical presentation and evaluation methods.
  • Analysis of melanoma growth patterns.
  • Discussion of pathologic staging of the neoplasm and regional lymph nodes.
  • Presentation of treatment strategies and associated outcomes.

Main Results:

  • Diagnosis at the earliest stage significantly impacts prognosis.
  • Understanding clinical presentation aids in early detection.
  • Pathologic staging is essential for determining appropriate treatment and predicting outcomes.

Conclusions:

  • Comprehensive understanding of melanoma's clinical aspects, staging, and treatment is vital.
  • Early diagnosis and prompt treatment improve survival rates for malignant melanoma patients.
  • Multidisciplinary approaches enhance the management and outcomes of this lethal neoplasm.