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Updated: Jun 20, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

Altered white matter microstructure in adolescent substance users.

Sunita Bava¹, Lawrence R Frank, Tim McQueeny

¹Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA.

Psychiatry Research

|August 25, 2009

Summary

This summary is machine-generated.

Chronic marijuana and alcohol use in teens impacts white matter integrity, particularly in fronto-parietal regions. This suggests potential disruptions in brain development and connectivity in adolescent substance users.

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Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Area of Science:

Neuroscience
Adolescent Development
Substance Use Research

Background:

Chronic marijuana and alcohol use in adolescence often co-occur.
Adolescent substance use is linked to central nervous system (CNS) alterations.
The impact of early cannabis and alcohol use on white matter integrity is not well understood.

Purpose of the Study:

To investigate the effects of chronic marijuana and alcohol use on white matter integrity in adolescents.
To characterize microstructural white matter changes in adolescent substance users compared to non-users.

Main Methods:

Diffusion Tensor Imaging (DTI) was used to assess white matter integrity.
36 marijuana and alcohol-using (MJ+ALC) adolescents and 36 non-using controls were evaluated.
Tract-based spatial statistics (TBSS) analyzed fractional anisotropy (FA) and mean diffusivity (MD) parameters.

Main Results:

MJ+ALC adolescents showed significantly lower FA in 10 regions, including the superior longitudinal fasciculus and frontal/temporal white matter.
Increased FA was observed in other regions like the right occipital lobe and internal capsule.
Altered mean diffusivity (MD) was noted in the right occipital lobe and left inferior longitudinal fasciculus.

Conclusions:

Adolescent marijuana and alcohol use may disrupt white matter integrity, particularly in fronto-parietal circuitry.
These disruptions could indicate aberrant axonal and myelin maturation, affecting fiber integrity.
Neuroadaptive processes may be occurring in alternate brain regions, warranting further investigation into cognitive processing impacts.