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Identification of significant regional genetic variations using continuous CNV values in aCGH data

Ki-Yeol Kim1, Gui Youn Lee, Jin Kim

  • 1Oral Cancer Research Institute, Yonsei University College of Dentistry, Seoul 120-752, Korea. kky1004@yuhs.ac

Genomics
|August 25, 2009
PubMed
Summary

We introduce shifted ANOVA, a novel method to detect chromosomal aberrations using array comparative genomic hybridization (aCGH). This approach identifies significantly altered genomic regions, aiding cancer research and diagnosis.

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Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
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