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Related Concept Videos

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Schizophrenia01:17

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...

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Related Experiment Video

Updated: Jun 20, 2026

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells
08:04

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells

Published on: November 19, 2020

Proteome and transcriptome analysis suggests oligodendrocyte dysfunction in schizophrenia.

Daniel Martins-de-Souza1

  • 1Max Planck Institute of Psychiatry, Kraepelinstrasse 2-10, D-80804 Munich, Germany. martins@mpipsykl.mpg.de

Journal of Psychiatric Research
|August 25, 2009
PubMed
Summary
This summary is machine-generated.

Schizophrenia

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Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
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Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Published on: December 4, 2014

Related Experiment Videos

Last Updated: Jun 20, 2026

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells
08:04

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells

Published on: November 19, 2020

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
08:33

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Published on: December 4, 2014

Area of Science:

  • Neuroscience
  • Biochemistry
  • Genetics

Background:

  • Schizophrenia affects 1% of the global population, with its biochemical basis incompletely understood.
  • Oligodendrocyte dysfunction is increasingly recognized as a key feature in schizophrenia.
  • Transcriptome and proteome analyses (TPA) are valuable tools for biomarker discovery and understanding disease mechanisms.

Purpose of the Study:

  • To review the role of oligodendrocytes in schizophrenia pathogenesis.
  • To integrate findings from transcriptome and proteome studies to elucidate disease mechanisms.
  • To contribute to a comprehensive understanding of schizophrenia's biochemical underpinnings.

Main Methods:

  • Systematic review of existing clinical and molecular studies.
  • Analysis of data from transcriptome and proteome analyses (TPA).
  • Focus on identifying oligodendrocyte-related factors in schizophrenia.

Main Results:

  • TPA studies consistently indicate oligodendrocyte dysfunction in schizophrenia.
  • Specific oligodendrocyte role players contributing to schizophrenia pathogenesis have been identified.
  • Integrated biochemical systems implicated in the disease are highlighted.

Conclusions:

  • Oligodendrocyte dysfunction is a significant factor in schizophrenia pathogenesis.
  • Understanding these oligodendrocyte roles offers new insights into the disease.
  • Further research into these pathways may improve schizophrenia treatment and diagnosis.