Related Experiment Video
Updated: Jun 20, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Personality trait predictors of bipolar disorder symptoms
Lena Catherine Quilty1, Martin Sellbom, Jennifer Lee Tackett
1Clinical Research Department, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Abstract:
The purpose of the current investigation was to examine the personality predictors of bipolar disorder symptoms, conceptualized as one-dimensional (bipolarity) or two-dimensional (mania and depression). A psychiatric sample (N=370; 45% women; mean age 39.50 years) completed the Revised NEO Personality Inventory and the Minnesota Multiphasic Personality Inventory -2. A model in which bipolar symptoms were represented as a single dimension provided a good fit to the data. This dimension was predicted by Neuroticism and (negative) Agreeableness. A model in which bipolar symptoms were represented as two separate dimensions of mania and depression also provided a good fit to the data. Depression was associated with Neuroticism and (negative) Extraversion, whereas mania was associated with Neuroticism, Extraversion and (negative) Agreeableness. Symptoms of bipolar disorder can be usefully understood in terms of two dimensions of mania and depression, which have distinct personality correlates.
Related Concept Videos
Bipolar Disorder
Borderline Personality Disorder
Genetic and Environmental Contributions
Borderline Personality...
Personality Theory by Eysenck and Eysenck
In the extroversion/introversion dimension, highly extroverted people are sociable, outgoing, and easily connect with others. In contrast,...
Traits and States
Personality Disorders: Schizotypal and Histrionic
Schizotypal Personality Disorder: Eccentric Behavior and Social Withdrawal
Schizotypal personality disorder is marked by odd or eccentric...
Personality Disorders: Paranoid and Schizoid
Paranoid Personality Disorder
Paranoid personality disorder is...
