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11:35
Replication of the Ordered, Nonredundant Library of Pseudomonas aeruginosa strain PA14 Transposon Insertion Mutants
Published on: May 4, 2018
Pseudomonas aeruginosa: a formidable and ever-present adversary
1Department of Microbiology, Harrogate District Hospital, Lancaster Park Road, Harrogate, North Yorkshire HG2 7SX, UK. kevin.kerr@hdft.nhs.uk
The Journal of Hospital Infection
|August 25, 2009
Summary
Pseudomonas aeruginosa infections are difficult to treat due to antimicrobial resistance. Environmental sources, particularly water, may play a significant role in hospital-acquired sporadic infections, necessitating new prevention strategies.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Hospital Epidemiology
Background:
- Pseudomonas aeruginosa is a significant cause of hospital-acquired infections, especially in vulnerable patients.
- High morbidity and mortality are associated with P. aeruginosa infections.
- Increasing antimicrobial resistance, including carbapenemase acquisition, complicates treatment.
Purpose of the Study:
- To investigate the role of environmental reservoirs in sporadic Pseudomonas aeruginosa infections.
- To identify strategies for preventing patient acquisition of P. aeruginosa in healthcare settings.
Main Methods:
- Review of existing literature on P. aeruginosa environmental reservoirs.
- Analysis of prospective studies on sporadic P. aeruginosa infections in hospitals.
- Epidemiological investigation of transmission routes.
Main Results:
- Environmental reservoirs, especially water, are implicated in P. aeruginosa outbreaks.
- Emerging evidence suggests environmental sources contribute to sporadic infections in intensive care units.
- Understanding environmental epidemiology is crucial for control.
Conclusions:
- Environmental sources, particularly water, are likely significant in the epidemiology of sporadic P. aeruginosa infections.
- Developing targeted strategies to interrupt environmental transmission is essential.
- Further research into environmental reservoirs will refine prevention and control measures.
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