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Updated: Jun 20, 2026
08:12
A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage
Published on: July 28, 2018
Deadly vasospasm.
D P H Eijking1, C L A Reichert, A M Wagenvoort
1Department of Intensive Care, Medisch Centrum Alkmaar, Alkmaar, The Netherlands. daaneijking@hotmail.com
Resuscitation
|August 25, 2009
Summary
Prinzmetal's variant angina (PVA) can lead to cardiac arrest from coronary vasospasm. This case suggests PVA may be linked to generalized vasospastic disorders, causing severe brain ischemia and brain death.
Area of Science:
- Cardiology
- Neurology
- Vascular Medicine
Background:
- Prinzmetal's variant angina (PVA) is characterized by coronary artery vasospasm.
- Myocardial infarction can result from severe coronary vasospasm.
Observation:
- A patient with PVA experienced cardiac arrest due to coronary vasospasm and myocardial infarction.
- Following resuscitation, the patient developed postanoxic brain injury.
- The patient rapidly deteriorated due to cerebral ischemia, suspected to be caused by cerebral vasospasm, leading to brain death.
Findings:
- This case describes the first known association between Prinzmetal's variant angina and cerebral vasospasm.
- The patient's clinical course suggests a potential generalized vasospastic disorder.
Implications:
- The findings suggest that patients with PVA may be at risk for cerebrovascular events due to vasospasm.
- Further research is warranted to explore the link between systemic vasospastic conditions and cardiovascular/neurological outcomes.
- This case highlights the importance of considering vasospasm in both coronary and cerebral circulations in specific patient populations.
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