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Updated: Jun 20, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
[Ecstasy poisoning in a 10-month-old infant]
1Centre d'évaluation et d'information sur la pharmacodépendance (CEIP), hospices civils de Lyon, 162 avenue Lacassagne, Lyon cedex 03, France.
Insights
Accidental ecstasy (MDMA) poisoning in a 10-month-old infant caused significant cardiovascular and neurological symptoms. Prompt medical care led to a full recovery, highlighting the risks of pediatric drug exposure in domestic settings.
Area of Science:
- Pediatric Toxicology
- Emergency Medicine
- Clinical Case Reports
Background:
- Ecstasy (3,4-methylenedioxymethamphetamine) use is increasingly prevalent beyond recreational settings.
- The domestic environment poses a risk for accidental pediatric exposure to illicit substances.
- Pediatric ecstasy poisoning is rare, with limited case reports available.
Observation:
- A 10-month-old infant presented with acute behavioral disturbances, including restlessness, hypertonia, and repetitive movements.
- Clinical manifestations included significant tachycardia, hypertension, agitation, mydriasis, and nystagmus.
- Differential diagnoses such as febrile seizures, cranial trauma, and encephalitis were systematically excluded.
Findings:
- Urinary toxicological screening confirmed the presence of methamphetamine, the primary metabolite of MDMA.
- Gas chromatography/mass spectrometry identified MDMA and caffeine in the infant's urine.
- The infant experienced a complete clinical recovery by the following morning.
Implications:
- This case underscores the potential for severe accidental drug poisoning in infants due to evolving substance use patterns.
- Increased awareness is needed regarding the accessibility of ecstasy in domestic environments.
- Prompt emergency department evaluation and toxicological analysis are crucial for managing pediatric drug ingestions.
Unlabelled:
We describe an accidental ecstasy poisoning in a 10-month-old girl.
Case Report:
A 10-month-old infant suddenly exhibited behavior disorders with restlessness, hypertonia, and repetitive movements. She was immediately taken to the Emergency Department. Cardiovascular (tachycardia and hypertension) and neurological disorders (major agitation, mydriasis, and nystagmus) were the predominating clinical features. The most common differential diagnoses including febrile convulsion, cranial trauma, or encephalitis were progressively ruled out. The urinary toxicological screen was positive for methamphetamine. MDMA, its main metabolite, and caffeine were subsequently detected in the infant's urine using gas chromatography/mass spectrometry. The child had completely recovered the next morning.
Comment:
Pediatric poisoning with ecstasy remains uncommon. To date, about 10 cases have been reported. All were due to accidental ingestion. Today, the use of ecstasy is no longer restricted to recreational purposes (rave parties, etc.) and it seems to be developing in private parties and in the home. The intrusion of this amphetamine-like drug into the domestic environment may expose young children to the accidental ingestion of ecstasy tablets.
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