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Related Concept Videos

Antigen Presenting Cells01:22

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

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Related Experiment Video

Updated: Jun 20, 2026

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

The ABC of dendritic cell development and function.

Rieneke van de Ven1, George L Scheffer, Rik J Scheper

  • 1Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.

Trends in Immunology
|August 25, 2009
PubMed
Summary

ATP-binding cassette (ABC) transporters regulate immune responses, particularly in dendritic cells (DCs). Their substrates may offer new avenues for DC-based chemo-immunotherapies.

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Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
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Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

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Last Updated: Jun 20, 2026

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro
06:12

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro

Published on: March 7, 2022

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
07:35

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

Published on: December 24, 2016

Area of Science:

  • Immunology
  • Cell Biology
  • Pharmacology

Background:

  • ATP-binding cassette (ABC) transporters are implicated in multidrug resistance and barrier organ defense.
  • Their substrates include immunomodulating agents like prostaglandins and leukotrienes.
  • ABC transporters are functionally expressed in immune cells, especially dendritic cells (DCs).

Purpose of the Study:

  • To review the roles of ABC transporters in dendritic cell (DC) development and function.
  • To explore the immunostimulatory potential of ABC transporter substrates.
  • To assess the benefit of this knowledge for DC-based chemo-immunotherapies.

Main Methods:

  • Literature review of studies on ABC transporters and immune cells.
  • Analysis of substrate profiles and their immunomodulatory functions.
  • Synthesis of information regarding DC biology and immunotherapy.

Main Results:

  • ABC transporters play significant roles in DC development and function.
  • Certain substrates of ABC transporters possess immunostimulatory properties.
  • Understanding these interactions can inform the development of novel therapeutic strategies.

Conclusions:

  • ABC transporters are key regulators of immune responses mediated by DCs.
  • Their substrates represent a potential source for developing DC-based chemo-immunotherapies.
  • Targeting ABC transporters or their substrates may enhance anti-cancer immunity.