Related Experiment Video
Updated: Jun 20, 2026
Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
Published on: July 28, 2023
Keloid treatment: is there a role for acellular human dermis (Alloderm)?
Nima P Patel1, A Lawrence Cervino
1Summa Health System/Northeast Ohio Universities College of Medicine, Division of Plastic and Reconstructive Surgery, Akron, Ohio 44304, USA. illin79@aol.com
Background:
Keloid management is faced with high recurrence rates. Keloid fibroblasts lack the normal negative feedback mechanism resulting in an exuberant scar formation. Alloderm doesn't undergo the same proliferative process as keloidal scar dermis.
Objective:
To evaluate Alloderm as a treatment modality for keloids
Methods:
A retrospective chart review of six patients with a total of eight large recurrent keloids was performed. Patients were treated with excision of the keloid followed by placement of Alloderm. Each patient was evaluated for recurrence and complications.
Results:
During follow-up ranging from 1 month to 4(1/2) years there were 0% recurrences. Two out of 8 (25%) had residual induration. one of the two patients with residual induration, required an intralesional injection of kenalog at 6 months post-op.
Conclusion:
Our results from this small study show that with the use of Alloderm after keloid excision, recurrence is low. Further study is warranted.
