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The Cholesterol, Hypertension, and Glucose Education (CHANGE) study for African Americans with diabetes: study design

Benjamin J Powers1, Joy L King, Robin Ali

  • 1Center for Health Services Research in Primary Care, Durham VAMC, Durham, NC 27705, USA. ben.powers@duke.edu

American Heart Journal
|August 25, 2009
PubMed

Insights

This study will test a nurse-led intervention to improve cardiovascular disease (CVD) outcomes in African American adults with diabetes by managing blood pressure, blood sugar, and cholesterol.

Area of Science:

  • Public Health
  • Cardiology
  • Endocrinology

Background:

  • Cardiovascular disease (CVD) and diabetes contribute significantly to mortality disparities between African Americans and white patients.
  • African Americans exhibit a higher CVD risk due to clustered risk factors.

Purpose of the Study:

  • To enhance CVD outcomes in African-American adults with diabetes.
  • To address modifiable risk factors: systolic blood pressure, glycosylated hemoglobin, and low-density lipoprotein cholesterol.

Main Methods:

  • 400 African American patients with diabetes were randomized into two groups: usual care or a nurse-administered disease-management intervention.
  • The intervention included monthly telephone support, patient self-management, and provider medication management.
  • Outcomes were assessed over 12 months, focusing on changes in glycosylated hemoglobin, systolic blood pressure, and LDL cholesterol.

Main Results:

  • The study aims to measure changes in key cardiovascular risk factors over a 12-month period.
  • Secondary outcomes include overall cardiovascular risk, aspirin use, and health behavior modifications.

Conclusions:

  • The proposed study has the potential to significantly reduce cardiovascular risk in African-American patients.
  • Addressing racial disparities in CVD is a critical public health goal.
Abstract

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