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Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

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Related Experiment Video

Updated: Jun 20, 2026

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
08:30

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Published on: March 15, 2018

Obesity and asthma.

David A Beuther1

  • 1National Jewish Health and Department of Pulmonary and Critical Care Medicine, University of Colorado at Denver Health Sciences Programs, Denver, CO 80206, USA. beutherd@njhealth.org

Clinics in Chest Medicine
|August 25, 2009
PubMed
Summary
This summary is machine-generated.

Obesity is linked to asthma, potentially causing airway changes and distinct asthma symptoms. This connection highlights a unique obese asthma phenotype needing further research.

Related Experiment Videos

Last Updated: Jun 20, 2026

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
08:30

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Published on: March 15, 2018

Area of Science:

  • Pulmonology
  • Immunology
  • Obesity Medicine

Background:

  • Population studies show a strong link between obesity and asthma.
  • Obesity can restrict lung function and narrow airways, potentially increasing airway hyper-responsiveness.
  • Obesity may influence asthma through inflammatory mechanisms, though relevance in humans is unclear.

Purpose of the Study:

  • To investigate the relationship between obesity and asthma.
  • To explore if obesity-associated inflammation plays a role in human asthma.
  • To characterize the distinct phenotype of obese asthma.

Main Methods:

  • Review of population-based studies.
  • Analysis of mouse models of asthma and obesity.
  • Examination of shared genetic and environmental factors.

Main Results:

  • Obesity is bidirectionally associated with asthma in a dose-dependent manner.
  • Obesity can lead to reduced lung volumes and airway diameter, contributing to hyper-responsiveness.
  • Obese asthma presents as a distinct phenotype with reduced lung volumes, minimal eosinophilic inflammation, altered treatment response, and poor control.

Conclusions:

  • Obesity is significantly associated with asthma, presenting a unique phenotype.
  • Obesity-related factors may contribute to asthma severity and treatment resistance.
  • Further research into shared factors and obesity-specific mechanisms is warranted.