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Soluble angiotensin-converting enzyme 2 in human heart failure: relation with myocardial function and clinical
Slava Epelman1, Kevin Shrestha, Richard W Troughton
1Department of Medicine, Section of Cardiology, Baylor College of Medicine, Houston, Texas, USA.
Background:
Angiotensin-converting enzyme 2 (ACE2) is an endogenous counterregulator of the renin-angiotensin system. The relationship between soluble ACE2 (sACE2), myocardial function, and clinical outcomes in patients with chronic systolic heart failure is not well established.
Methods And Results:
We measured sACE2 activity in 113 patients with chronic systolic heart failure (left ventricular ejection fraction [LVEF]
Conclusions:
Elevated plasma sACE2 activity was associated with greater severity of myocardial dysfunction and was an independent predictor of adverse clinical events.
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