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Updated: Jun 20, 2026

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013
Kojic acid-amino acid conjugates as tyrosinase inhibitors
Jin-Mi Noh1, Seon-Yeong Kwak, Hyo-Suk Seo
1School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Republic of Korea.
Abstract:
Kojic acid (KA), a well known tyrosinase inhibitor, has insufficient inhibitory activity and stability. We modified KA with amino acids and screened their tyrosinase inhibitory activity. Among them, kojic acid-phenylalanine amide (KA-F-NH(2)) showed the strongest inhibitory activity, which was maintained for over 3 months at 50 degrees C, and acted as a noncompetitive inhibitor as determined by kinetic analysis. It also exhibited dopachrome reducing activity. We also propose a new tyrosinase inhibition mechanism based on the docking simulation data.
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