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Related Concept Videos

Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Mitochondrial Membranes01:45

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
Regulation of Metabolism01:19

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...

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Related Experiment Video

Updated: Jun 20, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
08:34

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Published on: June 3, 2016

Mitochondrial (dys)function in adipocyte (de)differentiation and systemic metabolic alterations.

Aurélia De Pauw1, Silvia Tejerina, Martine Raes

  • 1Laboratory of Biochemistry and Cell Biology, University of Namur, 61 rue de Bruxelles, Namur, Belgium.

The American Journal of Pathology
|August 25, 2009
PubMed
Summary

Mitochondria are vital for fat cell development and function. Impaired mitochondrial activity in white adipocytes may link to obesity and diabetes, suggesting new therapeutic targets.

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Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
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Published on: June 3, 2016

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
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Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
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Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Published on: May 19, 2023

Area of Science:

  • Metabolic regulation and cellular biology.
  • Adipose tissue physiology and mitochondrial function.

Background:

  • Adipose tissue (BAT and WAT) regulates energy partitioning and metabolism.
  • White adipose tissue (WAT) and brown adipose tissue (BAT) undergo dynamic remodeling.
  • Mitochondrial roles in adipocyte differentiation and systemic metabolic health are under-reviewed.

Purpose of the Study:

  • To review the critical role of mitochondrial functions in adipogenesis and mature adipocytes.
  • To discuss white adipocyte responses to mitochondrial dysfunction.
  • To explore recent advances in mitochondrial research and their link to metabolic epidemics.

Main Methods:

  • Literature review focusing on mitochondrial function in adipocytes.
  • Analysis of cellular responses to mitochondrial impairment.
  • Synthesis of recent findings on mitochondrial dysfunction in metabolic diseases.

Main Results:

  • Mitochondrial activity is crucial for adipocyte differentiation and function.
  • Impaired mitochondrial function in white adipocytes elicits specific cellular responses.
  • Growing evidence links mitochondrial dysfunction to obesity, diabetes, and lipodystrophy.

Conclusions:

  • Mitochondria play a fundamental role in adipose tissue biology.
  • Mitochondrial dysfunction in adipocytes is implicated in metabolic disorders.
  • Targeting adipocyte mitochondria offers potential for novel therapeutic strategies.