Multiple myeloma presenting as bilateral orbital proptosis
Archana Malik1, Subina Narang, Uma Handa
1Department of Ophthalmology, Government Medical College and Hospital, Chandigarh - 160 032, India. drarchanag2002@yahoo.com
Indian Journal of Ophthalmology
|August 25, 2009
Summary
Bilateral proptosis, a rare sign of multiple myeloma, can occur without bone involvement. Early diagnosis through biochemical and histopathological tests is crucial for life-saving treatment in orbital myeloma.
Area of Science:
- Ophthalmology
- Hematology
- Oncology
Background:
- Orbital masses can present with varied etiologies.
- Bilateral proptosis necessitates a comprehensive differential diagnosis.
Observation:
- A 58-year-old male presented with painful, rapidly progressive bilateral proptosis and restricted ocular movements.
- Imaging revealed bilateral intraconal and extraconal soft tissue masses.
Findings:
- Diagnosis of multiple myeloma was confirmed via fine needle aspiration cytology, biopsy, and immunofixation.
- Skeletal survey showed no bony involvement, indicating a non-classical presentation of orbital myeloma.
Implications:
- Multiple myeloma should be considered in the differential diagnosis of bilateral proptosis, even without bone lesions.
- Extensive biochemical and histopathological investigations are vital for early diagnosis and timely, life-saving treatment of orbital myeloma.
