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Tracking large solid constructs suspended in a rotating bioreactor: A combined experimental and theoretical study.

L J Cummings¹, N B E Sawyer, S P Morgan

¹Department of Mathematical Sciences, New Jersey Institute of Technology, Newark, 07102-1982, USA. Linda.J.Cummings@njit.edu

Biotechnology and Bioengineering

|August 25, 2009

Summary

This study explores the motion of a suspended disc in a rotating bioreactor, crucial for tissue engineering. Experimental and theoretical results match, validating models for cell culture applications.

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Area of Science:

Fluid dynamics
Bioreactor engineering
Tissue engineering

Background:

Tissue engineering scaffolds require suspension in bioreactors for nutrient supply.
Rotating vessels are used to achieve "free fall" suspension of cell-laden constructs.
Understanding the motion of suspended objects is key to optimizing bioreactor design.

Purpose of the Study:

To experimentally and theoretically investigate the trajectory of a disc suspended in a rotating fluid-filled cylinder.
To validate a theoretical model for predicting the motion of suspended discs in bioreactors.
To inform tissue engineering protocols by analyzing fluid dynamics and nutrient concentration.

Main Methods:

Combined experimental and computational fluid dynamics (CFD) study.
Utilized a rotating cylindrical vessel with a suspended disc.
Compared experimental observations with theoretical predictions from Cummings and Waters (2007).

Main Results:

Identified three distinct motion regimes: fixed suspension, oscillatory motion, and orbital motion.
Achieved good agreement between experimental data and theoretical predictions.
CFD enabled determination of nutrient concentration fields, which are experimentally inaccessible.

Conclusions:

The study successfully validates a model for predicting disc motion in rotating bioreactors.
Findings support the application of this method for tissue engineering, enabling optimized nutrient delivery.
The research provides insights into fluid dynamics relevant to cell culture and scaffold development.