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Related Concept Videos

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

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Inflammatory Bowel Disease IV: Pharmacological Management

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Dosage Regimen: Individualization01:24

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Related Experiment Video

Updated: Jun 20, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Calcitriol ointment: optimizing psoriasis therapy.

Linda F Stein Gold1

  • 1Henry Ford Hospital, Detroit, MI, USA. lstein@hfhs.org

Journal of Drugs in Dermatology : JDD
|August 26, 2009
PubMed
Summary
This summary is machine-generated.

Topical calcitriol ointment effectively treats plaque psoriasis with minimal side effects and no impact on calcium levels. This vitamin D3 therapy offers a flexible option for managing psoriasis symptoms.

Related Experiment Videos

Last Updated: Jun 20, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Topical calcitriol, the active form of vitamin D3, is approved for plaque psoriasis treatment in the U.S.
  • It has a history of use in topical psoriasis therapy internationally.

Purpose of the Study:

  • To evaluate the efficacy and safety of calcitriol 3 microg/g ointment for plaque psoriasis.
  • To assess calcitriol's role in combination therapy with corticosteroids or UVB phototherapy.

Main Methods:

  • Vehicle-controlled clinical trials were conducted.
  • Studies examined calcitriol ointment in monotherapy and combination regimens.

Main Results:

  • Calcitriol 3 microg/g ointment significantly improved psoriasis symptoms.
  • Adverse effects were infrequent, and calcium homeostasis remained unaffected even with long-term use.
  • Combination therapy studies demonstrated its utility with other treatments.

Conclusions:

  • Calcitriol 3 microg/g ointment is an effective and safe topical treatment for plaque psoriasis.
  • It offers treatment flexibility and can be integrated into various therapeutic strategies.
  • It aligns with American Academy of Dermatology goals for psoriasis management.