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A longitudinal analysis of cognitive dysfunction, coping, and depression in multiple sclerosis
Amanda R Rabinowitz1, Peter A Arnett
1Department of Psychology, The Pennsylvania State University, University Park, PA 16802-3106, USA. arr200@psu.edu
Neuropsychology
|August 26, 2009
Summary
Adaptive coping strategies protect individuals with multiple sclerosis (MS) from depression linked to cognitive dysfunction. Maladaptive coping, however, increases depression risk in MS patients with cognitive deficits.
Area of Science:
- Neuroscience
- Psychology
- Clinical Medicine
Background:
- Depression is a common comorbidity in multiple sclerosis (MS).
- Cognitive dysfunction is prevalent in MS and may contribute to depression.
- The role of coping strategies in this relationship remains incompletely understood.
Purpose of the Study:
- To examine the roles of coping styles as moderators and mediators in the development of depression among individuals with MS.
- To investigate how cognitive dysfunction impacts depression through different coping mechanisms.
Main Methods:
- A longitudinal study design was employed.
- Coping styles were assessed using indices derived from the COPE (Carver, Scheier, & Weintraub, 1989), operationalized as active, avoidant, and a combined index.
- Cognitive functioning and depression were evaluated over time.
Main Results:
- Coping style significantly moderated the relationship between cognitive dysfunction and depression.
- Adaptive coping buffered the negative impact of cognitive deficits on depression.
- Maladaptive coping exacerbated the risk of depression in the presence of cognitive dysfunction.
- Cognitive dysfunction partially mediated the relationship with depression through its effects on coping strategies.
Conclusions:
- Coping strategies play a crucial role in the development of depression in individuals with MS.
- Interventions aimed at promoting adaptive coping may help mitigate depression risk associated with cognitive decline in MS.
- Cognitive deficits may impair the capacity for adaptive coping, increasing vulnerability to depression.
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