Related Experiment Video
Updated: Jun 20, 2026

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Water uptake by substituted amylose tablets: experimentation and numerical simulation
H W Wang1, S Kyriacos, L Cartilier
1Faculty of Pharmacy, University of Montreal, Montreal, QC, Canada.
Background:
Substituted amylose (SA) has been developed as excipient for direct compression matrices in the formulation of sustained release solid dosage forms.
Method:
The gel performance of SA for controlling water diffusion was studied by measuring water content in SA tablets prepared by direct compression.
Results:
The SA gel was not freely swelling and results indicate that water content in equilibrium state was dependent on tablet size but not on compression force. The presence of electrolyte and hydrophobic lubricant played an effective role in adjusting water diffusion in SA gel. In addition, a numerical model based on finite difference method was developed that exhibits a high goodness of fit to experimental result. The output of the model was not only the macroscopic water content value but also the water distribution within SA tablets.
Related Concept Videos
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence
Methods for Studying Drug Absorption: In vitro
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...

