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Water uptake by substituted amylose tablets: experimentation and numerical simulation
H W Wang1, S Kyriacos, L Cartilier
1Faculty of Pharmacy, University of Montreal, Montreal, QC, Canada.
Drug Development and Industrial Pharmacy
|August 26, 2009
Summary
Substituted amylose (SA) tablets control water diffusion effectively for sustained release. Water content depends on tablet size, not compression force, and can be adjusted by electrolytes and lubricants.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Substituted amylose (SA) is a novel excipient for direct compression matrices.
- SA is utilized in formulating sustained-release solid dosage forms.
Purpose of the Study:
- To investigate the gel performance of SA in controlling water diffusion.
- To analyze water content and distribution within SA tablets.
Main Methods:
- Tablets were prepared by direct compression.
- Water content in SA tablets was measured.
- A numerical model based on the finite difference method was developed.
Main Results:
- SA gel exhibited non-free swelling behavior.
- Equilibrium water content was influenced by tablet size but not compression force.
- Electrolytes and hydrophobic lubricants modulated water diffusion.
- The numerical model accurately predicted experimental results, providing water distribution data.
Conclusions:
- SA demonstrates potential as a controlled-release excipient.
- Tablet size and formulation additives significantly impact water diffusion.
- The developed numerical model is a valuable tool for predicting drug release behavior.
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