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Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism
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Published on: December 18, 2013

A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with

Abdellah Allali-Hassani1, Gregory A Wasney, Irene Chau

  • 1Structural Genomics Consortium, University of Toronto, 101 College Street, Room 839, MaRS Centre, South Tower, Toronto, ON, Canada M5G 1L7.

The Biochemical Journal
|August 26, 2009
PubMed

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Mutations01:35

Mutations

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RNA Stability

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RNA Stability01:53

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Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
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Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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