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Live Imaging of Antifungal Activity by Human Primary Neutrophils and Monocytes in Response to A. fumigatus
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A novel fungal pathogen under the spotlight--Acremonium spp. associated fungaemia in an immunocompetent host

Tugrul Purnak, Yavuz Beyazit, Gulsen Ozkaya Sahin

    Mycoses
    |August 26, 2009
    PubMed

    Insights

    Acremonium fungal infections, though rare in immunocompetent individuals, can cause bloodstream infections (fungaemia) in patients with chronic renal failure. Successful treatment involved catheter removal and voriconazole therapy.

    Area of Science:

    • Mycology
    • Infectious Diseases
    • Clinical Medicine

    Background:

    • Acremonium spp. are ubiquitous fungi typically causing infections in severely immunocompromised individuals.
    • Catheter-related bloodstream infections (CRBSI) are a significant concern in patients with indwelling medical devices.

    Observation:

    • A case of Acremonium spp. fungaemia associated with a subclavian catheter is reported in a patient with chronic renal failure.
    • The patient was considered relatively immunocompetent, making this presentation unusual.

    Findings:

    • Successful treatment was achieved with voriconazole after catheter removal.
    • The patient received a loading dose of 400 mg voriconazole followed by 200 mg twice daily.

    Implications:

    • This case highlights the potential for Acremonium spp. to cause invasive infections in less immunocompromised hosts.
    • Early diagnosis and appropriate antifungal therapy, such as voriconazole, are crucial for managing Acremonium fungaemia.

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