Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pulmonary Tuberculosis II

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...

Pulmonary Tuberculosis IV

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...

Pulmonary Tuberculosis III

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:

Tuberculosis

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...

Pulmonary Tuberculosis I

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...

Pulmonary Tuberculosis V

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Reconstructing the reconstructed: Outcomes of redo-urethroplasty for recurrent urethral strictures.

Actas urologicas espanolas·2026

Same author

Anatomical-biochemical discordance and prognostic role of bone metastases in advanced MTC treated with [¹⁷⁷Lu]Lu-DOTA-TATE.

BMC cancer·2025

Same author

Why so many doses, and why now?

European thyroid journal·2025

Same author

Could Serum Collectin-11, surfactant protein-A and D be suitable biomarkers for assessing pulmonary damage caused by Rhodococcus equi infection in foals on large farms?

Polish journal of veterinary sciences·2024

Same author

The relationship between thorax computed tomography findings and prognosis in patients diagnosed with COVID-19.

European review for medical and pharmacological sciences·2023

Same author

Factors affecting anxiety, depression, and stress among patients with hepatocellular carcinoma during COVID-19 pandemic.

European review for medical and pharmacological sciences·2023

Search research articles

Related Experiment Video

Updated: Jun 20, 2026

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Published on: September 19, 2016

Peripheral immune response in pulmonary tuberculosis.

E Aktas¹, F Ciftci, S Bilgic

¹Department of Immunology, Institute of Experimental Medicine (DETAE), Istanbul University, Sehremini 34393, Istanbul, Turkey.

Scandinavian Journal of Immunology

|August 26, 2009

Summary

This summary is machine-generated.

Investigating pulmonary tuberculosis (PTB) immune responses, this study found lower levels of key cytokines in PTB patients. CD8(+) T cells producing both Th1 and Th2 cytokines may be crucial in mycobacterial immune responses.

More Related Videos

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

Published on: October 5, 2015

Related Experiment Videos

Last Updated: Jun 20, 2026

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Published on: September 19, 2016

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

Published on: October 5, 2015

Area of Science:

Immunology
Infectious Diseases
Cellular Biology

Background:

Pulmonary tuberculosis (PTB) pathogenesis involves cellular immunity and delayed-type hypersensitivity.
The precise mechanisms of immune response in PTB require further clarification.
While Th1 cells are linked to healing, Th2 and CD8(+) T cell responses may worsen PTB severity.

Purpose of the Study:

To investigate peripheral blood immune responses in patients with pulmonary tuberculosis.
To compare cytokine profiles and T cell activation between PTB patients and healthy controls.

Main Methods:

Flow cytometry was used to determine intracytoplasmic cytokine content (IL-2, IL-4, IL-5, IL-10, IFN-gamma) in CD8(+) T cells and lymphocytes.
Cytometric Bead Array (CBA) measured serum cytokine levels (IL-2, IL-4, IL-5, IL-10, IFN-gamma, TNF-alpha).
Study groups comprised young male soldiers with PTB and healthy male soldiers without PTB history.

Main Results:

No significant differences in T, B, NK cell percentages or HLA-DR expression between groups.
Higher percentages of CD3(+)HLA-DR(+) activated T cells were observed in the PTB group.
Significantly lower intracytoplasmic IL-2, IL-4, IL-5, IL-10 in lymphocytes and IFN-gamma in CD8(+) T cells in PTB patients.
Lower serum levels of IL-2, IL-4, IL-5, and TNF-alpha were found in PTB patients compared to controls.

Conclusions:

Peripheral immune responses in PTB are characterized by reduced levels of key cytokines.
CD8(+) T cells producing a mix of Th1 and Th2 cytokines appear to play a significant role in the peripheral immune response to mycobacteria.