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Updated: Jun 20, 2026

Hydrolysis of a Ni-Schiff-Base Complex Using Conditions Suitable for Retention of Acid-labile Protecting Groups
Published on: April 6, 2017
One-pot synthesis of highly functionalized seleno amino acid derivatives
Haixia Liu1, Alexander Dömling
1Departments of Pharmaceutical Sciences and Chemistry, University of Pittsburgh, BST3 11019, Pittsburgh, PA 1526, USA.
Abstract:
We herein provide a new and rapid protocol to generate derivatives of seleno amino acid, including methyl selenocysteine, selenomethionine, and selenocystine. Applying the isocyanide-based multicomponent reaction Ugi-4C-5C reaction, we show that each of the commercially available seleno amino acids are good substrate for these reactions and can be used together with complementary oxocomponents and isocyanides to generate highly diverse functionalized selenium-containing compounds. These compounds might become useful tools for applications in chemical biology to elucidate the role of selenium in biochemistry.
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