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Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration
Published on: June 9, 2023
Antiproliferative activity against MCF-7 breast cancer cells by diamino-triazaspirodiene antifolates
Xiang Ma1, Renee Ser-Peng Woon, Paul Chi-Lui Ho
1Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore 117543. phacwk@nus.edu.sg
Abstract:
Two triazaspirodienes, having similar phenoxy propyloxy side chain, were identified as potent mammalian dihydrofolate reductase inhibitors; one having a 6,5-spiro bicyclic ring system (IC(50) = 2.3 nm) and the other a 6,6-spiro bicyclic system (IC(50) = 6.9 nm). They also showed more than 50% antiproliferative activity against the MCF-7 breast cancer cells at 20 microm. This study demonstrated the potential lead of the diamino-triazaspirodienes in anticancer chemotherapeutical agents' discovery.
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