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Related Concept Videos

The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...

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Related Experiment Video

Updated: Jun 20, 2026

Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization
08:52

Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization

Published on: August 16, 2015

System-level feedbacks control cell cycle progression.

Orsolya Kapuy1, Enuo He, Sandra López-Avilés

  • 1Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, Oxford, UK.

FEBS Letters
|August 26, 2009
PubMed
Summary
This summary is machine-generated.

Cell cycle progression is driven by cyclin-dependent protein kinases (Cdks) and cyclins. Computational models reveal that bistability in the Cdk-control system ensures irreversible transitions, directing cell cycle advancement.

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Last Updated: Jun 20, 2026

Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization
08:52

Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization

Published on: August 16, 2015

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
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Measuring Cell Cycle Progression Kinetics with Metabolic Labeling and Flow Cytometry
11:23

Measuring Cell Cycle Progression Kinetics with Metabolic Labeling and Flow Cytometry

Published on: May 22, 2012

Area of Science:

  • Biochemistry
  • Cell Biology
  • Systems Biology

Background:

  • Cell cycles are fundamental for life, regulated by cyclin-dependent protein kinases (Cdks) and cyclins.
  • Cdk1/CycB activity oscillates, driving DNA replication and mitosis.
  • Previous models suggest complex regulatory networks govern cell cycle dynamics.

Purpose of the Study:

  • To investigate the role of bistability in cell cycle control.
  • To elucidate the biochemical mechanisms ensuring unidirectional cell cycle progression.
  • To propose a systems-level model for Cdk regulation.

Main Methods:

  • Computational modeling of biochemical reaction networks.
  • Analysis of system-level feedback mechanisms (positive and double-negative).
  • Simulation of Cdk-control system dynamics.

Main Results:

  • Identified low and high kinase activity states as alternative stable steady states.
  • Demonstrated that bistability arises from system-level feedback loops.
  • Showed bistability underlies irreversible transitions in Cdk activity.

Conclusions:

  • Bistability in the Cdk-control system is crucial for cell cycle progression.
  • System-level feedback generates bistability, ensuring directional cell cycle advancement.
  • This model provides a framework for understanding cell cycle regulation and irreversibility.