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Updated: Jan 25, 2026

3D Cine Magnetic Resonance Imaging of Respiratory Motion in Mechanically Ventilated Mice and Rats
Published on: September 19, 2025
A failed case of weaning from a mechanical ventilator with lorazepam successfully accomplished by ziprasidone
David R Spiegel1, Navindra Ramdath
1Eastern Virginia Medical School, Department of Psychiatry and Behavioral Sciences, Norfolk, VA 23507, USA. spiegedr@evms.edu
Abstract:
Chronic Obstructive Pulmonary Disease (COPD) exacerbations are potential medical emergencies treated with bronchodilators, glucocorticoids and supplemental oxygen. However, in extreme cases, adequate treatment requires mechanical ventilation via endotracheal intubation to correct the acid-base imbalance created by the disease process. We present a case of a 52-year-old female with COPD exacerbation requiring intubation who failed extubation multiple times while concurrently being treated with lorazepam, for agitation. Based on the evidence for increased carbon dioxide retention associated with benzodiazepine use, we weaned the patient off the lorazepam which in turn allowed the patient to be successfully weaned off the ventilator.
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