C-5 substituted heteroaryl-3-pyridinecarbonitriles as PKCtheta inhibitors: part II
Amar S Prashad1, Daniel Wang, Joan Subrath
1Wyeth Research, Chemical Sciences, 401 N. Middletown Road, Pearl River, NY 10965, United States. prashaa@wyeth.com
Abstract:
We previously reported that a 3-pyridinecarbonitrile analog with a furan substituent at C-5 and a 4-methylindol-5-ylamino substituent at C-4, 1, was a potent inhibitor of PKCtheta (IC50=4.5 nM). Replacement of the C-5 furan ring of 1 with bicyclic heteroaryl rings, led to compounds with significantly improved potency against PKCtheta. Analog 6b with a 4-methylindol-5-ylamino group at C-4 and a 5-[(4-methylpiperazin-1-yl)methyl]-1-benzofuran-2-yl group at C-5 had an IC50 value of 0.28 nM for the inhibition of PKCtheta.
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