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Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection

Matthew J Robinson1, Fabiola Osorio, Marcela Rosas

  • 1Immunobiology Laboratory, Cancer Research UK, London Research Institute, Lincoln's Inn Fields Laboratories, London WC2A 3PX, England, UK.

The Journal of Experimental Medicine
|August 26, 2009
PubMed

Insights

Dendritic cells (DCs) use Dectin-2, a pattern recognition receptor (PRR), to detect fungi. Dectin-2 signals through Syk and CARD9, influencing T cell responses and adaptive immunity during fungal infections.

Area of Science:

  • Immunology
  • Microbiology
  • Cell Biology

Background:

  • Innate immune cells utilize pattern recognition receptors (PRRs) to detect pathogens and initiate immune responses.
  • Dectin-1, a PRR for fungi, signals via Syk kinase and CARD9, crucial for Th17 responses.
  • The C-type lectin Dectin-2's role in fungal recognition and immune signaling requires further elucidation.

Purpose of the Study:

  • To investigate the signaling pathway of Dectin-2 in response to fungal particles.
  • To determine Dectin-2's contribution to dendritic cell (DC) activation and immune responses.
  • To elucidate Dectin-2's role in adaptive immunity against fungal infections, particularly Candida albicans.

Main Methods:

  • Utilized a model of Candida albicans infection.
  • Investigated Dectin-2 signaling through Syk and CARD9 pathways.
  • Examined the effects of Dectin-2 blockade on innate and adaptive immune responses, including T cell cytokine production (IL-17, Th1).

Main Results:

  • Dectin-2 signals via Syk and CARD9, contributing to DC activation by fungal particles.
  • Dectin-2 couples to Syk indirectly via the FcRgamma chain, distinct from Dectin-1.
  • Blockade of Dectin-2 impaired IL-17 production by T cells and, with Dectin-1 absence, reduced Th1 responses.

Conclusions:

  • Dectin-2 is a significant fungal PRR that activates the Syk-CARD9 innate signaling pathway.
  • Dectin-2 plays a key role in activating DCs and regulating adaptive immune responses to fungal infections.
  • Dectin-2 influences both Th17 and Th1 responses, highlighting its importance in orchestrating immunity against fungi.

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