Related Experiment Video
Updated: Jun 20, 2026
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
The relation between microalbuminuria and coronary collateral vessel development in patients with unstable coronary
Ramazan Topsakal1, Mehmet G Kaya, Mustafa Duran
1Department of Cardiology, Erciyes University School of Medicine, Kayseri, Turkey.
Insights
Microalbuminuria, a marker of vascular disease, is linked to poorer coronary collateral vessel development in unstable coronary artery disease patients. This finding suggests microalbuminuria negatively impacts cardiovascular health.
Area of Science:
- Cardiology
- Nephrology
- Vascular Biology
Background:
- Microalbuminuria is a marker for systemic vascular disease and predicts cardiovascular risk.
- The specific relationship between microalbuminuria and coronary collateral vessel (CCV) development is not well understood.
- Unstable coronary artery disease (USCAD) presents a critical context for investigating cardiovascular markers.
Purpose of the Study:
- To investigate the association between microalbuminuria and CCV development in patients with USCAD.
- To determine if microalbuminuria impacts the formation of coronary collateral vessels in non-diabetic, non-hypertensive USCAD patients.
- To clarify the role of microalbuminuria as a potential indicator of impaired vascular adaptation in coronary artery disease.
Main Methods:
- Radioimmunoassay measurement of microalbuminuria in 24-hour urine collections.
- Coronary angiography to assess coronary artery stenosis and CCV development (Rentrop score >= 1).
- Comparative analysis between a microalbuminuria group (n=26) and a normoalbuminuria control group (n=80) of USCAD patients.
Main Results:
- CCV development was observed in 23% of patients with microalbuminuria versus 74% in the normoalbuminuria group.
- A significant inverse correlation was found between microalbuminuria and CCV development (r = -0.15, P = 0.006).
- Patients with microalbuminuria demonstrated significantly poorer CCV development compared to those with normoalbuminuria.
Conclusions:
- Microalbuminuria is associated with impaired coronary collateral vessel development in patients with unstable coronary artery disease.
- These findings suggest that microalbuminuria negatively influences the body's ability to form compensatory blood vessels in the context of coronary artery disease.
- Microalbuminuria may serve as a relevant biomarker for assessing vascular health and collateralization capacity in USCAD patients.
Abstract:
Microalbuminuria, considered a marker for systemic vascular disease, is a significant predictor of increased risk for cardiovascular morbidity and mortality in the general population. The relationship between microalbuminuria and cardiovascular disease is unknown. The aim of this study is to examine the association between microalbuminuria and coronary collateral vessel (CCV) development in nondiabetic and nonhypertensive patients with unstable coronary artery disease (USCAD). One hundred and six patients that had USCAD without hypertension and diabetes participated in the study. Microalbuminuria was assessed by radioimmunoassay in 24-h urine collections performed on the first day, and coronary angiography was performed 2-4 days after admissions. In total, 26 patients (mean age 56+/-14 years) had the criteria of the microalbuminuria group and 80 patients with normoalbuminuria (mean age 59+/-11 years), who had one or more diseased vessels with 80% or more stenosis, were included in the control group. The CCVs are graded according to the Rentrop scoring system and a Rentrop grade >or=1 was accepted as CCV development. CCV development was detected in eight (23%) of 26 patients in the microalbuminuria group and in 53 (74%) of 80 patients in the normoalbuminuria group. CCV development in the patients in the normoalbuminuria group was significantly different from that of the patients in the microalbuminuria group (r = -0.15, P = 0.006). In conclusion, these findings suggest that CCV development is poorer in the microalbuminuria group than the normoalbuminuria group. This study shows that in patients with USCAD, microalbuminuria, which is related to systemic vascular disease, affects CCV development negatively.
Related Concept Videos
01:26Coronary Artery Disease II: Pathophysiology
01:30Coronary Artery Disease I: Introduction
01:28Diabetic Nephropathy
01:30Acute Coronary Syndrome III: Diagnostic Studies