Related Experiment Video
Updated: Jun 20, 2026
09:44
Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array
Published on: March 8, 2024
Active pixel sensor array for high spatio-temporal resolution electrophysiological recordings from single cell to
Luca Berdondini1, Kilian Imfeld, Alessandro Maccione
1Neuroscience and Brain Technologies, Italian Institute of Technology, Via Morego 30, 16163, Genova, Italy. Luca.Berdondini@iit.it
Lab on a Chip
|August 26, 2009
Summary
This study introduces a new chip-based platform for studying neuronal networks. The device offers high-resolution electrophysiological recordings, advancing neuroscience research on brain circuits.
Area of Science:
- Neuroscience
- Biophysics
- Electrical Engineering
Background:
- Investigating neuronal circuitry requires high-resolution tools for capturing electrical activity.
- Existing platforms may lack the spatial or temporal resolution needed for comprehensive network analysis.
Purpose of the Study:
- To present a novel chip-based electrophysiological platform for in-vitro neuronal preparations.
- To enable the study of micro- and macro-circuitry with high fidelity.
Main Methods:
- Development of a 64x64 microelectrode array (MEA) using Complementary Metal Oxide Semiconductor (CMOS) technology.
- Integration of in-pixel low-noise amplifiers and high-speed random addressing logic.
- Real-time acquisition system capable of recording at 7.8 kHz/electrode.
Main Results:
- Achieved high spatial resolution (21 microm electrode separation) and temporal resolution (down to 8 micros).
- Demonstrated successful acquisition of neuronal signals from single cells to large-scale networks.
- Platform provides low-noise amplification (11 microVrms).
Conclusions:
- The chip-based platform facilitates detailed investigation of neuronal activity across multiple scales.
- This technology advances the study of complex neuronal preparations and network dynamics.
- Offers a powerful tool for neuroscience research and development.
