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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Interictal quantitative EEG in migraine: a blinded controlled study.

Marte Helene Bjørk1, Lars J Stovner, Morten Engstrøm

  • 1Department of Neuroscience, Norwegian University of Science and Technology (NTNU), MTFS, 7489, Trondheim, Norway. marte.bjork@ntnu.no

The Journal of Headache and Pain
|August 26, 2009
PubMed
Summary

Migraineurs exhibit increased theta brainwave activity between attacks, suggesting subtle interictal brain dysfunction. This study compared electroencephalography (EEG) in migraine patients and controls, controlling for pre-attack changes.

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Area of Science:

  • Neuroscience
  • Clinical Neurology

Background:

  • Abnormal electroencephalography (EEG) findings are common in migraineurs.
  • Previous studies often fail to account for pre-ictal or post-ictal effects on EEG.
  • Interictal EEG evaluation is crucial for understanding migraine pathophysiology.

Purpose of the Study:

  • To compare interictal EEG in migraineurs and controls, minimizing interference from recent or upcoming attacks.
  • To investigate pre-ictal EEG changes on the painful side during a subsequent migraine attack.
  • To explore correlations between clinical migraine variables and EEG parameters.

Main Methods:

  • A blinded, controlled study comparing interictal EEG data from 33 migraineurs and 31 headache-free controls.
  • Analysis of absolute power, asymmetry, and relative power across delta, theta, and alpha frequency bands in different cortical regions.
  • Correlation analysis between EEG variables and clinical factors like attack frequency, duration, pain intensity, and sensory sensitivities.

Main Results:

  • Migraineurs showed significantly increased relative theta power across all cortical regions compared to controls.
  • Increased delta activity was observed in the fronto-central region of migraineurs, particularly on the side of future pain.
  • Headache intensity correlated with increased delta activity in age-adjusted analyses.

Conclusions:

  • Migraineurs exhibit a global increase in relative theta activity during interictal periods.
  • Findings suggest a subtle, persistent brain dysfunction in migraineurs between attacks.
  • The study design effectively controlled for pre-ictal EEG changes, providing robust interictal data.