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Related Experiment Videos

Tissue perfusion in anaesthetised sheep.

B M Weaver1, G E Staddon, M R Pearson

  • 1Wellcome Comparative Anaesthetic Laboratory, Department of Veterinary Surgery, University of Bristol, UK.

Comparative Biochemistry and Physiology. A, Comparative Physiology
|January 1, 1990
PubMed
Summary

This study measured tissue perfusion in anesthetized sheep using radioactive microspheres and thermodilution. Results were comparable to conscious sheep and horses, accounting for physiological differences.

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Area of Science:

  • Veterinary Physiology
  • Cardiovascular Research
  • Anesthesiology

Background:

  • Accurate measurement of tissue perfusion is crucial in physiological research.
  • Understanding hemodynamic parameters in anesthetized animals is essential for comparative studies.

Purpose of the Study:

  • To quantify tissue perfusion in anesthetized sheep.
  • To compare these measurements with existing data from conscious sheep and horses.

Main Methods:

  • Radioactive microsphere method used for tissue perfusion measurement in seven sheep.
  • Cardiac output determined via Fick principle and thermodilution.
  • Anesthesia and ventilation maintained near normal arterial carbon dioxide tension.

Main Results:

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  • Tissue perfusion data obtained in anesthetized sheep.
  • Results showed similarity to previously published values for conscious sheep.
  • Comparisons with anesthetized horses also revealed similarities, considering physiological variations.

Conclusions:

  • Anesthesia and ventilation protocols maintained physiological parameters suitable for perfusion measurement.
  • Hemodynamic values in anesthetized sheep are comparable to conscious sheep and horses when adjusted for body composition.