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Published on: February 27, 2026
Bilateral adrenal leiomyosarcoma treated with multiple local therapies
Shinsuke Hamada1, Keiichi Ito, Musashi Tobe
1Department of Urology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, Japan.
International Journal of Clinical Oncology
|August 26, 2009
Summary
Adrenal leiomyosarcoma, a rare cancer, can present as nonfunctioning tumors. Despite aggressive treatment including surgery, chemotherapy, and radiation, the disease spread systemically, leading to patient death.
Area of Science:
- Oncology
- Surgical Pathology
- Radiology
Background:
- Adrenal tumors are rare, and leiomyosarcoma is an even rarer subtype.
- Nonfunctioning adrenal tumors can present diagnostic challenges, potentially masking underlying malignancy.
Observation:
- A 62-year-old woman presented with bilateral adrenal tumors initially presumed nonfunctioning.
- The larger right adrenal tumor showed intratumoral hemorrhage, while the left was cystic.
- Histological examination of the right adrenal tumor revealed leiomyosarcoma.
Findings:
- The patient developed widespread metastases including pleural, bone, femoral, liver, kidney, and pancreatic lesions.
- Despite multimodal therapy (surgery, chemotherapy, radiofrequency ablation, radiotherapy), the disease progressed systemically.
- Local treatments provided effective control of metastatic lesions.
Implications:
- This case highlights the aggressive nature of adrenal leiomyosarcoma and the challenges in managing metastatic disease.
- Multidisciplinary treatment approaches are crucial for local control of metastatic lesions.
- Further research into targeted therapies for adrenal leiomyosarcoma is warranted.
